Liver Biopsy in Transplantation: Nonalcoholic Fatty Liver Disease and the Eosinophils
ثبت نشده
چکیده
Liver biopsy is important in the perioperative management of liver transplantation with regard to the preoperative evaluation of donor liver graft, especially to rule out steatotic liver, and the postoperative diagnosis of acute cellular rejection (ACR), especially to differentiate ACR from other causes of liver dysfunction. In both situations, liver biopsy is mandatory to confirm the diagnosis. The recent increases in metabolic syndrome and diabetes mellitus in the general population have led to an increased incidence of liver steatosis, even in donors without a history of excessive alcohol intake. Nonalcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver injuries that resemble alcoholic hepatitis, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). NASH is the progressed stage of NAFLD and further progression results in fibrosis and cirrhosis, which might also be an indication for liver transplantation. ACR is one of the most serious adverse events after transplantation. It is often difficult to distinguish it from recurrent hepatitis C virus (HCV), and prompt treatment with an appropriate diagnosis is important. In this chapter, the indications for liver biopsy and the histologic findings for the diagnosis of NAFLD and ACR are described.
منابع مشابه
The Effect of Purslane Seeds on Fasting Blood Glucose and Serum Liver Enzymes in Patients with Nonalcoholic Fatty Livers
Objective: Nonalcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease in the world and it is one of the liver transplantation causes. The present study aimed to investigate the effect of Purslane seeds on anthropometric parameters, fasting blood glucose (FBS), and liver enzymes in patients with nonalcoholic fatty livers. Materials and Methods: in this clinical trial, 5...
متن کاملبررسی اثر سیلیمارین بر کبد چرب غیر الکلی کودکان: کارآزمایی بالینی متقاطع
Background and purpose: Nonalcoholic fatty liver disease is one of the most common causes of chronic liver disease and is a major public health problem worldwide. In recent years, the prevalence of nonalcoholic fatty liver disease has increased in children and adolescents. This study aimed to investigate the effect of silymarin on children with nonalcoholic fatty liver disease. Materials and...
متن کاملInhibition of 5-Lipoxygenase inhibitor zileuton in high-fat diet-induced nonalcoholic fatty liver disease progression model
Objective(s): Arachidonic Acid/5-lipoxygenase (AA/5-LOX) pathway connects lipid metabolism and proinflammatory cytokine, which are both related to the development and progression of nonalcoholic fatty liver disease (NAFLD). Therefore, the present study was designed to investigate the role of AA/5-LOX pathway in progression of NAFLD, and the effect of zileuton, an inhibitor of 5-LOX, in this mod...
متن کاملThe Effect of Aerobic Continuous Training on Myonectin, Insulin Resistance and Liver Enzymes in Rats with Nonalcoholic Fatty Liver Disease
Background. Non-alcoholic fatty liver disease, is the most common reason of liver disorders that can be controlled by dieting and regular physical activity. Objectives. The aim of this study was to investigate the effect of aerobic continuous training on serum levels of myonectin, insulin resistance and liver enzymes in rats with non-alcoholic fatty liver disease. Methods. Thirty-four male W...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012